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Disulfide Bond-mediated Multimerization of Ask1 and Its Reduction by Thioredoxin-1 Regulate H(2)O(2)-induced c-Jun NH(2)-terminal Kinase Activation and Apoptosis
Apoptosis signal-regulated kinase-1 (Ask1) lies upstream of a major redox-sensitive pathway leading to the activation of Jun NH(2)-terminal kinase (JNK) and the induction of apoptosis. We found that cell exposure to H(2)O(2) caused the rapid oxidation of Ask1, leading to its multimerization through...
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| Главные авторы: | , , , |
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| Формат: | Artigo |
| Язык: | Inglês |
| Опубликовано: |
The American Society for Cell Biology
2007
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| Предметы: | |
| Online-ссылка: | https://ncbi.nlm.nih.gov/pmc/articles/PMC1995733/ https://ncbi.nlm.nih.gov/pubmed/17652454 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1091/mbc.E07-05-0491 |
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