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REDOX Reaction at ASK1-Cys250 Is Essential for Activation of JNK and Induction of Apoptosis
ASK1 cysteine oxidation allows JNK activation upon oxidative stress. Trx1 negatively regulates this pathway by reducing the oxidized cysteines of ASK1. However, precisely how oxidized ASK1 is involved in JNK activation and how Trx1 regulates ASK1 oxidoreduction remains elusive. Here, we describe two...
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| Autors principals: | , , |
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| Format: | Artigo |
| Idioma: | Inglês |
| Publicat: |
The American Society for Cell Biology
2009
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| Matèries: | |
| Accés en línia: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2777923/ https://ncbi.nlm.nih.gov/pubmed/19570911 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1091/mbc.E09-03-0211 |
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