ASK1 is required for sustained activations of JNK/p38 MAP kinases and apoptosis

Apoptosis signal-regulating kinase (ASK) 1 is activated in response to various cytotoxic stresses including TNF, Fas and reactive oxygen species (ROS) such as H(2)O(2), and activates c-Jun NH(2)-terminal kinase (JNK) and p38. However, the roles of JNK and p38 signaling pathways during apoptosis have...

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Bibliographic Details
Main Authors: Tobiume, Kei, Matsuzawa, Atsushi, Takahashi, Takumi, Nishitoh, Hideki, Morita, Kei-ichi, Takeda, Kohsuke, Minowa, Osamu, Miyazono, Kohei, Noda, Tetsuo, Ichijo, Hidenori
Format: Artigo
Language:Inglês
Published: Oxford University Press 2001
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Scientific Reports
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC1083842/
https://ncbi.nlm.nih.gov/pubmed/11266364
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/embo-reports/kve046
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