The inotropic effect of cardioactive glycosides in ventricular myocytes requires Na(+)–Ca(2)(+) exchanger function

Glycoside-induced cardiac inotropy has traditionally been attributed to direct Na(+)–K(+)-ATPase inhibition, causing increased intracellular [Na(+)] and consequent Ca(2+) gain via the Na(+)–Ca(2+) exchanger (NCX). However, recent studies suggested alternative mechanisms of glycoside-induced inotropy...

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Hlavní autoři: Altamirano, Julio, Li, Yanxia, DeSantiago, Jaime, Piacentino, Valentino, Houser, Steven R, Bers, Donald M
Médium: Artigo
Jazyk:Inglês
Vydáno: Blackwell Science Inc 2006
Témata:
Cardiovascular
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC1995692/
https://ncbi.nlm.nih.gov/pubmed/16825310
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1113/jphysiol.2006.111252
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