Pur α binds to rCGG repeats and modulates repeat-mediated neurodegeneration in a Drosophila model of Fragile X Tremor/Ataxia Syndrome

Fragile X-associated tremor/ataxia syndrome (FXTAS) is a recently recognized neurodegenerative disorder in fragile X premutation carriers with FMR1 alleles containing 55-200 CGG repeats. Previously, we developed a Drosophila model of FXTAS and demonstrated that transcribed premutation repeats alone...

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Autores principales: Jin, Peng, Duan, Ranhui, Qurashi, Abrar, Qin, Yunlong, Tian, Donghua, Rosser, Tracie C., Liu, Huijie, Feng, Yue, Warren, Stephen T.
Formato: Artigo
Lenguaje:Inglês
Publicado: 2007
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Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC1994817/
https://ncbi.nlm.nih.gov/pubmed/17698009
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.neuron.2007.07.020
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