SIRNA-Directed In Vivo Silencing of Androgen Receptor Inhibits the Growth of Castration-Resistant Prostate Carcinomas

BACKGROUND: Prostate carcinomas are initially dependent on androgens, and castration or androgen antagonists inhibit their growth. After some time though, tumors become resistant and recur with a poor prognosis. The majority of resistant tumors still expresses a functional androgen receptor (AR), fr...

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Autors principals: Compagno, Daniel, Merle, Carole, Morin, Aurélie, Gilbert, Cristèle, Mathieu, Jacques R. R., Bozec, Aline, Mauduit, Claire, Benahmed, Mohammed, Cabon, Florence
Format: Artigo
Idioma:Inglês
Publicat: Public Library of Science 2007
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Research Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC1994591/
https://ncbi.nlm.nih.gov/pubmed/17925854
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0001006
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