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Mechanistic Studies of the Flavoenzyme Tryptophan 2-Monooxygenase: Deuterium and (15)N Kinetic Isotope Effects on Alanine Oxidation by an L-Amino Acid Oxidase

Tryptophan 2-monooxygenase (TMO) from Pseudomonas savastanoi catalyzes the oxidative decarboxylation of L-tryptophan during the biosynthesis of indoleacetic acid. Structurally and mechanistically the enzyme is a member of the family of L-amino acid oxidases. Deuterium and (15)N kinetic isotope effec...

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Hlavní autoři: Ralph, Erik C., Anderson, Mark A., Cleland, W. Wallace, Fitzpatrick, Paul F.
Médium: Artigo
Jazyk:Inglês
Vydáno: 2006
Témata:
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC1994567/
https://ncbi.nlm.nih.gov/pubmed/17176107
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/bi061894o
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