Akt-Mediated Activation of HIF-1 in Pulmonary Vascular Endothelial Cells by S-Nitrosoglutathione

S-nitrosoglutathione (GSNO) stabilizes the α-subunit of hypoxia inducible factor-1 (HIF-1) in normoxic cells, but not in the presence of PI3K inhibitors. In this report, the biochemical pathway by which GSNO alters PI3K/Akt activity to modify HIF-1 expression was characterized in Cos cells and prima...

ver descrição completa

Na minha lista:
Detalhes bibliográficos
Main Authors: Carver, D. Jeannean, Gaston, Benjamin, deRonde, Kimberly, Palmer, Lisa A.
Formato: Artigo
Idioma:Inglês
Publicado em: American Thoracic Society 2007
Assuntos:
Oxidative-Nitrosative Stress and Post-Translational Protein Modifications: Implications to Lung Structure-Function Relations
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC1994227/
https://ncbi.nlm.nih.gov/pubmed/17541013
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1165/rcmb.2006-0289SM
Tags: Adicionar Tag
Sem tags, seja o primeiro a adicionar uma tag!

Registos relacionados