Inhibition of ICMT Induces Endothelial Cell Apoptosis through GRP94

Isoprenylcysteine-O-carboxyl methyltransferase (ICMT) catalyzes methylation of proteins containing a C-terminal CAAX motif. We have previously shown that chemical inhibition of ICMT caused endothelial cell apoptosis, an effect correlated with decreased Ras and RhoA carboxyl methylation and GTPase ac...

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Autors principals: Lu, Qing, Harrington, Elizabeth O., Newton, Julie, Jankowich, Matthew, Rounds, Sharon
Format: Artigo
Idioma:Inglês
Publicat: American Thoracic Society 2007
Matèries:
Oxidative-Nitrosative Stress and Post-Translational Protein Modifications: Implications to Lung Structure-Function Relations
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC1899353/
https://ncbi.nlm.nih.gov/pubmed/17347446
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1165/rcmb.2006-0301SM
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