Two Cys residues essential for von Willebrand factor multimer assembly in the Golgi

Von Willebrand factor (VWF) dimerizes through C-terminal CK domains, and VWF dimers assemble into multimers in the Golgi by forming intersubunit disulfide bonds between D3 domains. This unusual oxidoreductase reaction requires the VWF propeptide (domains D1D2), which acts as an endogenous pH-depende...

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Main Authors: Purvis, Angie R., Gross, Julia, Dang, Luke T., Huang, Ren-Huai, Kapadia, Milan, Townsend, R. Reid, Sadler, J. Evan
Format: Artigo
Jezik:Inglês
Izdano: National Academy of Sciences 2007
Teme:
Biological Sciences
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC1994133/
https://ncbi.nlm.nih.gov/pubmed/17895385
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0705175104
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