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Fibroblast-like synoviocytes support B-cell pseudoemperipolesis via a stromal cell–derived factor-1– and CD106 (VCAM-1)–dependent mechanism

B-cell accumulation and formation of ectopic germinal centers are characteristic changes in the diseased joints of patients with rheumatoid arthritis (RA). Earlier studies suggested that interactions between B lymphocytes and specialized synovial “nurse-like” cells peculiar to the RA synovium may be...

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Autors principals: Burger, Jan A., Zvaifler, Nathan J., Tsukada, Nobuhiro, Firestein, Gary S., Kipps, Thomas J.
Format: Artigo
Idioma:Inglês
Publicat: American Society for Clinical Investigation 2001
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Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC199194/
https://ncbi.nlm.nih.gov/pubmed/11160154
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