Inhibition of STAT3 signaling leads to apoptosis of leukemic large granular lymphocytes and decreased Mcl-1 expression

Large granular lymphocyte (LGL) leukemia is characterized by the expansion of antigen-activated cytotoxic T lymphocytes. These leukemic cells are resistant to Fas-mediated apoptosis despite expressing high levels of Fas. We found that leukemic LGL from 19 patients displayed high levels of activated...

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Main Authors: Epling-Burnette, P.K., Liu, Jin Hong, Catlett-Falcone, Robyn, Turkson, James, Oshiro, Marc, Kothapalli, Ravi, Li, Yongxiang, Wang, Ju-Ming, Yang-Yen, Hsin-Fang, Karras, James, Jove, Richard, Loughran, Thomas P.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Clinical Investigation 2001
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC199188/
https://ncbi.nlm.nih.gov/pubmed/11160159
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