Inhibition of STAT3 signaling leads to apoptosis of leukemic large granular lymphocytes and decreased Mcl-1 expression

Large granular lymphocyte (LGL) leukemia is characterized by the expansion of antigen-activated cytotoxic T lymphocytes. These leukemic cells are resistant to Fas-mediated apoptosis despite expressing high levels of Fas. We found that leukemic LGL from 19 patients displayed high levels of activated...

Full beskrivning

Sparad:
Bibliografiska uppgifter
Huvudupphovsmän: Epling-Burnette, P.K., Liu, Jin Hong, Catlett-Falcone, Robyn, Turkson, James, Oshiro, Marc, Kothapalli, Ravi, Li, Yongxiang, Wang, Ju-Ming, Yang-Yen, Hsin-Fang, Karras, James, Jove, Richard, Loughran, Thomas P.
Materialtyp: Artigo
Språk:Inglês
Publicerad: American Society for Clinical Investigation 2001
Ämnen:
Article
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC199188/
https://ncbi.nlm.nih.gov/pubmed/11160159
Taggar: Lägg till en tagg
Inga taggar, Lägg till första taggen!

Liknande verk