Structural changes at microtubule ends accompanying GTP hydrolysis: Information from a slowly hydrolyzable analogue of GTP, guanylyl (α,β)methylenediphosphonate

Microtubules are dynamic polymers that interconvert between periods of slow growth and fast shrinkage. The energy driving this nonequilibrium behavior comes from the hydrolysis of GTP, which is required to destabilize the microtubule lattice. To understand the mechanism of this destabilization, cryo...

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Veröffentlicht in:	Proc Natl Acad Sci U S A
Hauptverfasser:	Müller-Reichert, Thomas, Chrétien, Denis, Severin, Fedor, Hyman, Anthony A.
Format:	Artigo
Sprache:	Inglês
Veröffentlicht:	National Academy of Sciences 1998
Schlagworte:	Biological Sciences
Online-Zugang:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC19892/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/9520422/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.95.7.3661
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