Structural changes at microtubule ends accompanying GTP hydrolysis: Information from a slowly hydrolyzable analogue of GTP, guanylyl (α,β)methylenediphosphonate

Microtubules are dynamic polymers that interconvert between periods of slow growth and fast shrinkage. The energy driving this nonequilibrium behavior comes from the hydrolysis of GTP, which is required to destabilize the microtubule lattice. To understand the mechanism of this destabilization, cryo...

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Pubblicato in:	Proc Natl Acad Sci U S A
Autori principali:	Müller-Reichert, Thomas, Chrétien, Denis, Severin, Fedor, Hyman, Anthony A.
Natura:	Artigo
Lingua:	Inglês
Pubblicazione:	National Academy of Sciences 1998
Soggetti:	Biological Sciences
Accesso online:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC19892/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/9520422/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.95.7.3661
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