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Cul4A is required for hematopoietic stem-cell engraftment and self-renewal

Several hematopoietic stem-cell (HSC) regulators are controlled by ubiquitin-mediated proteolysis, so the ubiquitin pathway might modulate HSC function. However, this hypothesis has not been formally tested. Cul4A encodes a core subunit of one ubiquitin ligase. Whereas Cul4A-deficient embryos die in...

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Hlavní autoři: Li, Binghui, Jia, Nan, Waning, David L., Yang, Feng-Chun, Haneline, Laura S., Chun, Kristin T.
Médium: Artigo
Jazyk:Inglês
Vydáno: American Society of Hematology 2007
Témata:
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC1988932/
https://ncbi.nlm.nih.gov/pubmed/17616641
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2006-12-064154
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