Salinosporamide A (NPI-0052) potentiates apoptosis, suppresses osteoclastogenesis, and inhibits invasion through down-modulation of NF-κB–regulated gene products

Salinosporamide A (also called NPI-0052), recently identified from the marine bacterium Salinispora tropica, is a potent inhibitor of 20S proteasome and exhibits therapeutic potential against a wide variety of tumors through a poorly understood mechanism. Here we demonstrate that salinosporamide A p...

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Bibliographische Detailangaben
Hauptverfasser: Ahn, Kwang Seok, Sethi, Gautam, Chao, Ta-Hsiang, Neuteboom, Saskia T. C., Chaturvedi, Madan M., Palladino, Michael A., Younes, Anas, Aggarwal, Bharat B.
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Society of Hematology 2007
Schlagworte:
Chemokines, Cytokines, and Interleukins
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC1988928/
https://ncbi.nlm.nih.gov/pubmed/17609425
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2007-04-084996
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