Proteasome Regulator Marizomib (NPI-0052) Exhibits Prolonged Inhibition, Attenuated Efflux, and Greater Cytotoxicity than Its Reversible Analogs

The present study was undertaken to compare the cellular transport characteristics of [(3)H]NPI-0052 (1R,4R,5S)-4-(2-chloroethyl)-1-((S)-((S)-cyclohex-2-enyl)(hydroxy)methyl)-5-methyl-6-oxa-2-azabicyclo[3.2.0]heptane-3,7-dione (marizomib; salinosporamide A) and [(3)H]NPI-0047 (1R,4R, 5S)-1-((S)-((S)...

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Detalhes bibliográficos
Main Authors: Obaidat, Amanda, Weiss, Jeffrey, Wahlgren, Brett, Manam, Rama R., Macherla, Venkat R., McArthur, Katherine, Chao, Ta-Hsiang, Palladino, Michael A., Lloyd, G. Kenneth, Potts, Barbara C., Enna, Salvatore J., Neuteboom, Saskia T. C., Hagenbuch, Bruno
Formato: Artigo
Idioma:Inglês
Publicado em: The American Society for Pharmacology and Experimental Therapeutics 2011
Assuntos:
Chemotherapy, Antibiotics, and Gene Therapy
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3083100/
https://ncbi.nlm.nih.gov/pubmed/21303921
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1124/jpet.110.177824
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