Anacardic acid (6-nonadecyl salicylic acid), an inhibitor of histone acetyltransferase, suppresses expression of nuclear factor-κB–regulated gene products involved in cell survival, proliferation, invasion, and inflammation through inhibition of the inhibitory subunit of nuclear factor-κBα kinase, leading to potentiation of apoptosis

Anacardic acid (6-pentadecylsalicylic acid) is derived from traditional medicinal plants, such as cashew nuts, and has been linked to anticancer, anti-inflammatory, and radiosensitization activities through a mechanism that is not yet fully understood. Because of the role of nuclear factor-κB (NF-κB...

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Detalhes bibliográficos
Main Authors: Sung, Bokyung, Pandey, Manoj K., Ahn, Kwang Seok, Yi, Tingfang, Chaturvedi, Madan M., Liu, Mingyao, Aggarwal, Bharat B.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society of Hematology 2008
Assuntos:
Chemokines, Cytokines, and Interleukins
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2384122/
https://ncbi.nlm.nih.gov/pubmed/18349320
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2007-10-117994
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