Lentiviral-mediated RNAi inhibition of Sbds in murine hematopoietic progenitors impairs their hematopoietic potential

Shwachman-Diamond syndrome (SDS) is a rare multisystem disorder characterized by exocrine pancreatic insufficiency, multilineage hematopoietic dysfunction, and metaphyseal chondrodysplasia. Bone marrow dysfunction is present in nearly all patients with SDS, with neutropenia being the most common abn...

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Autors principals: Rawls, Amy S., Gregory, Alyssa D., Woloszynek, Jill R., Liu, Fulu, Link, Daniel C.
Format: Artigo
Idioma:Inglês
Publicat: American Society of Hematology 2007
Matèries:
Hematopoiesis
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC1988923/
https://ncbi.nlm.nih.gov/pubmed/17638857
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2006-03-007112
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