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Cdc6 is regulated by E2F and is essential for DNA replication in mammalian cells

Cdc6 has a critical regulatory role in the initiation of DNA replication in yeasts, but its function in mammalian cells has not been characterized. We show here that Cdc6 is expressed selectively in proliferating but not quiescent mammalian cells, both in culture and within tissues of intact animals...

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Udgivet i:Proc Natl Acad Sci U S A
Principais autores: Yan, Zhen, DeGregori, James, Shohet, Ralph, Leone, Gustavo, Stillman, Bruce, Nevins, Joseph R., Williams, R. Sanders
Format: Artigo
Sprog:Inglês
Udgivet: National Academy of Sciences 1998
Fag:
Biological Sciences
Online adgang:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC19882/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/9520412/
https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.95.7.3603
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