Fez1/Lzts1 absence impairs Cdk1/Cdc25C interaction during mitosis and predisposes to cancer development

The FEZ1/LZTS1 (LZTS1) protein is frequently downregulated in human cancers of different histotypes. LZTS1 is expressed in normal tissues, and its introduction in cancer cells inhibits cell growth and suppresses tumorigenicity, owing to an accumulation of cells in G2/M. Here we define its role in ce...

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Hauptverfasser: Vecchione, Andrea, Baldassarre, Gustavo, Ishii, Hideshi, Nicoloso, Milena S., Belletti, Barbara, Petrocca, Fabio, Zanesi, Nicola, Fong, Louise Y.Y., Battista, Sabrina, Guarnieri, Daniela, Baffa, Raffaele, Alder, Hansjuerg, Farber, John L., Donovan, Peter J., Croce, Carlo M.
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2007
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC1987708/
https://ncbi.nlm.nih.gov/pubmed/17349584
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ccr.2007.01.014
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