The binding of doxepin to histamine H1-receptors in guinea-pig and rat brain.

The affinity constant for doxepin obtained from inhibition of histamine-induced contraction of guinea-pig intestinal smooth muscle at 30 degrees C was 2.6 +/- 0.18 X 10(10)M-1. The slope of a Schild plot was not significantly different from unity. The affinity constant of doxepin did not vary marked...

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Main Authors: Aceves, J., Mariscal, S., Morrison, K. E., Young, J. M.
Format: Artigo
Sprog:Inglês
Udgivet: Nature Publishing Group 1985
Fag:
Research Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC1987281/
https://ncbi.nlm.nih.gov/pubmed/3978317
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