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In vivo interaction of prostacyclin with an inhibitor of cyclic nucleotide phosphodiesterase, HL 725.

Prostacyclin (PGI2) inactivates platelets by stimulation of adenylate cyclase, and its effect can be potentiated in vitro by simultaneous inhibition of cyclic AMP phosphodiesterase. The interaction of synthetic PGI2 and the potent phosphodiesterase inhibitor HL 725 was studied in a model of systemic...

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Hlavní autoři: Darius, H., Lefer, A. M., Leprán, I., Smith, J. B.
Médium: Artigo
Jazyk:Inglês
Vydáno: Nature Publishing Group 1985
Témata:
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC1987149/
https://ncbi.nlm.nih.gov/pubmed/2985163
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