Transcriptional regulation of the thyrotropin-releasing hormone gene by leptin and melanocortin signaling

Starvation causes a rapid reduction in thyroid hormone levels in rodents. This adaptive response is caused by a reduction in thyrotropin-releasing hormone (TRH) expression that can be reversed by the administration of leptin. Here we examined hypothalamic signaling pathways engaged by leptin to upre...

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Detalhes bibliográficos

Publicado no:	J Clin Invest
Principais autores:	Harris, Mark, Aschkenasi, Carl, Elias, Carol F., Chandrankunnel, Annie, Nillni, Eduardo A., Bjørbæk, Christian, Elmquist, Joel K., Flier, Jeffrey S., Hollenberg, Anthony N.
Formato:	Artigo
Idioma:	Inglês
Publicado em:	American Society for Clinical Investigation 2001
Assuntos:	Article
Acesso em linha:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC198547/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/11134186/ https://ncbi.nlm.nih.govhttps://doi.org/10.1172/JCI10741
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