Crystal structure of the catalytic domain of human tumor necrosis factor-α-converting enzyme

Tumor necrosis factor-α (TNFα) is a cytokine that induces protective inflammatory reactions and kills tumor cells but also causes severe damage when produced in excess, as in rheumatoid arthritis and septic shock. Soluble TNFα is released from its membrane-bound precursor by a membrane-anchored prot...

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Detalles Bibliográficos
Autores principales: Maskos, Klaus, Fernandez-Catalan, Carlos, Huber, Robert, Bourenkov, Gleb P., Bartunik, Hans, Ellestad, George A., Reddy, Pranitha, Wolfson, Martin F., Rauch, Charles T., Castner, Beverly J., Davis, Raymond, Clarke, Howard R. G., Petersen, Melissa, Fitzner, Jeffrey N., Cerretti, Douglas Pat, March, Carl J., Paxton, Raymond J., Black, Roy A., Bode, Wolfram
Formato: Artigo
Lenguaje:Inglês
Publicado: The National Academy of Sciences 1998
Materias:
Biological Sciences
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC19849/
https://ncbi.nlm.nih.gov/pubmed/9520379
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