Crystal structure of the catalytic domain of human tumor necrosis factor-α-converting enzyme

Tumor necrosis factor-α (TNFα) is a cytokine that induces protective inflammatory reactions and kills tumor cells but also causes severe damage when produced in excess, as in rheumatoid arthritis and septic shock. Soluble TNFα is released from its membrane-bound precursor by a membrane-anchored prot...

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Veröffentlicht in:	Proc Natl Acad Sci U S A
Hauptverfasser:	Maskos, Klaus, Fernandez-Catalan, Carlos, Huber, Robert, Bourenkov, Gleb P., Bartunik, Hans, Ellestad, George A., Reddy, Pranitha, Wolfson, Martin F., Rauch, Charles T., Castner, Beverly J., Davis, Raymond, Clarke, Howard R. G., Petersen, Melissa, Fitzner, Jeffrey N., Cerretti, Douglas Pat, March, Carl J., Paxton, Raymond J., Black, Roy A., Bode, Wolfram
Format:	Artigo
Sprache:	Inglês
Veröffentlicht:	National Academy of Sciences 1998
Schlagworte:	Biological Sciences
Online-Zugang:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC19849/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/9520379/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.95.7.3408
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Crystal structure of the catalytic domain of human tumor necrosis factor-α-converting enzyme

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