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Persistent expression of human clotting factor IX from mouse liver after intravenous injection of adeno-associated virus vectors

We previously found that gene transduction by adeno-associated virus (AAV) vectors in cell culture can be stimulated over 100-fold by treatment of the target cells with agents that affect DNA metabolism, such as irradiation or topoisomerase inhibitors. Here we show that previous γ-irradiation increa...

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Udgivet i:Proc Natl Acad Sci U S A
Principais autores: Koeberl, Dwight D., Alexander, Ian E., Halbert, Christine L., Russell, David W., Miller, A. Dusty
Format: Artigo
Sprog:Inglês
Udgivet: National Academy of Sciences 1997
Fag:
Biological Sciences
Online adgang:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC19807/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/9037069/
https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.94.4.1426
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