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SPARC Upregulates MT1-MMP Expression, MMP-2 Activation, and the Secretion and Cleavage of Galectin-3 in U87MG Glioma Cells

Secreted protein acidic and rich in cysteine (SPARC) is highly expressed in human gliomas and promotes glioma invasion. We have shown by cDNA array analysis that SPARC upregulates membrane type 1-matrix metalloproteinase (MT1-MMP) and matrix metalloproteinase-2 (MMP-2) transcripts. To confirm these...

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Detalhes bibliográficos
Main Authors: McClung, Heather M., Thomas, Stacey L., Osenkowski, Pamela, Toth, Marta, Menon, Priya, Raz, Avraham, Fridman, Rafael, Rempel, Sandra A.
Formato: Artigo
Idioma:Inglês
Publicado em: 2007
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC1978544/
https://ncbi.nlm.nih.gov/pubmed/17490812
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.neulet.2007.04.037
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