The Inactive 44-kDa Processed Form of Membrane Type 1 Matrix Metalloproteinase (MT1-MMP) Enhances Proteolytic Activity via Regulation of Endocytosis of Active MT1-MMP

Membrane type 1 (MT1) matrix metalloproteinase (MMP-14) is a membrane-tethered MMP considered to be a major mediator of pericellular proteolysis. MT1-MMP is regulated by a complex array of mechanisms, including processing and endocytosis that determine the pool of active proteases on the plasma memb...

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Detalhes bibliográficos
Main Authors: Cho, Jin-Ah, Osenkowski, Pamela, Zhao, Huiren, Kim, Seaho, Toth, Marta, Cole, Kristina, Aboukameel, Amro, Saliganan, Allen, Schuger, Lucia, Bonfil, R. Daniel, Fridman, Rafael
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2008
Assuntos:
Enzyme Catalysis and Regulation
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2427325/
https://ncbi.nlm.nih.gov/pubmed/18413312
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M708943200
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