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MVB-12, a Fourth Subunit of Metazoan ESCRT-I, Functions in Receptor Downregulation

After ligand binding and endocytosis, cell surface receptors can continue to signal from endosomal compartments until sequestered from the cytoplasm. An important mechanism for receptor downregulation in vivo is via the inward budding of receptors into intralumenal vesicles to form specialized endos...

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Hlavní autoři: Audhya, Anjon, McLeod, Ian X., Yates, John R., Oegema, Karen
Médium: Artigo
Jazyk:Inglês
Vydáno: Public Library of Science 2007
Témata:
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC1978536/
https://ncbi.nlm.nih.gov/pubmed/17895996
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0000956
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