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Factor H–mediated cell surface protection from complement is critical for the survival of PNH erythrocytes
Paroxysmal nocturnal hemoglobinuria (PNH) cells are partially (type II) or completely (type III) deficient in GPI-linked complement regulatory proteins CD59 and CD55. PNH III erythrocytes circulate 6 to 60 days in vivo. Why these cells are not lysed as rapidly by complement as unprotected foreign ce...
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| Main Authors: | , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
American Society of Hematology
2007
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC1976366/ https://ncbi.nlm.nih.gov/pubmed/17554058 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2007-04-083170 |
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