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Essential Role of Surface-Bound Complement Factor H in Controlling Immune Complex–Induced Arthritis

Factor H (fH) is an endogenous negative regulator of the alternative pathway (AP) that binds polyanions as well as complement activation fragments C3b and C3d. The AP is both necessary and sufficient to develop collagen Ab–induced arthritis (CAIA) in mice; the mechanisms whereby normal control of th...

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Main Authors: Banda, Nirmal K., Mehta, Gaurav, Ferreira, Viviana P., Cortes, Claudio, Pickering, Matthew C., Pangburn, Michael K., Arend, William P., Holers, V. Michael
格式: Artigo
語言:Inglês
出版: AAI 2013
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在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC3607402/
https://ncbi.nlm.nih.gov/pubmed/23436934
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4049/jimmunol.1203271
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