Essential Role of Surface-Bound Complement Factor H in Controlling Immune Complex–Induced Arthritis

Factor H (fH) is an endogenous negative regulator of the alternative pathway (AP) that binds polyanions as well as complement activation fragments C3b and C3d. The AP is both necessary and sufficient to develop collagen Ab–induced arthritis (CAIA) in mice; the mechanisms whereby normal control of th...

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Détails bibliographiques
Auteurs principaux: Banda, Nirmal K., Mehta, Gaurav, Ferreira, Viviana P., Cortes, Claudio, Pickering, Matthew C., Pangburn, Michael K., Arend, William P., Holers, V. Michael
Format: Artigo
Langue:Inglês
Publié: AAI 2013
Sujets:
Innate Immunity and Inflammation
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC3607402/
https://ncbi.nlm.nih.gov/pubmed/23436934
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4049/jimmunol.1203271
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