Essential Role of Surface-Bound Complement Factor H in Controlling Immune Complex–Induced Arthritis

Factor H (fH) is an endogenous negative regulator of the alternative pathway (AP) that binds polyanions as well as complement activation fragments C3b and C3d. The AP is both necessary and sufficient to develop collagen Ab–induced arthritis (CAIA) in mice; the mechanisms whereby normal control of th...

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Main Authors: Banda, Nirmal K., Mehta, Gaurav, Ferreira, Viviana P., Cortes, Claudio, Pickering, Matthew C., Pangburn, Michael K., Arend, William P., Holers, V. Michael
Formáid: Artigo
Teanga:Inglês
Foilsithe: AAI 2013
Ábhair:
Innate Immunity and Inflammation
Rochtain Ar Líne:https://ncbi.nlm.nih.gov/pmc/articles/PMC3607402/
https://ncbi.nlm.nih.gov/pubmed/23436934
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4049/jimmunol.1203271
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