Factor H–mediated cell surface protection from complement is critical for the survival of PNH erythrocytes

Paroxysmal nocturnal hemoglobinuria (PNH) cells are partially (type II) or completely (type III) deficient in GPI-linked complement regulatory proteins CD59 and CD55. PNH III erythrocytes circulate 6 to 60 days in vivo. Why these cells are not lysed as rapidly by complement as unprotected foreign ce...

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Hlavní autoři: Ferreira, Viviana P., Pangburn, Michael K.
Médium: Artigo
Jazyk:Inglês
Vydáno: American Society of Hematology 2007
Témata:
Red Cells
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC1976366/
https://ncbi.nlm.nih.gov/pubmed/17554058
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2007-04-083170
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