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Platelet particle formation by anti–GPIIIa49-66 Ab, Ca(2+) ionophore A23187, and phorbol myristate acetate is induced by reactive oxygen species and inhibited by dexamethasone blockade of platelet phospholipase A(2), 12-lipoxygenase, and NADPH oxidase
An HIV antibody (Ab) against platelet integrin GPIIIa49-66 induces complement-independent platelet particle formation by the elaboration of reactive oxygen species (ROS) downstream of the activation of the platelet NADPH oxidase by the 12-lipoxygenase (12-LO) product 12(S)-HETE. To determine whether...
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| Main Authors: | , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
American Society of Hematology
2007
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC1976358/ https://ncbi.nlm.nih.gov/pubmed/17545506 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2006-10-054064 |
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