Complement-independent Ab-induced peroxide lysis of platelets requires 12-lipoxygenase and a platelet NADPH oxidase pathway

Antiplatelet GPIIIa49–66 Ab of HIV-related thrombocytopenic patients induces thrombocytopenia and platelet fragmentation by the generation of peroxide and other reactive oxygen species (ROS). Here we report the presence of a functional platelet NADPH oxidase pathway that requires activation by the p...

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Main Authors: Nardi, Michael, Feinmark, Steven J., Hu, Liang, Li, Zongdong, Karpatkin, Simon
Formato: Artigo
Idioma:Inglês
Publicado: American Society for Clinical Investigation 2004
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Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC379327/
https://ncbi.nlm.nih.gov/pubmed/15057303
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI200420726
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