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Enzymatic synthesis of DNA on glycerol nucleic acid templates without stable duplex formation between product and template

Glycerol nucleic acid (GNA) is an interesting alternative base-pairing system based on an acyclic, glycerol-phosphate backbone repeat unit. The question of whether DNA polymerases can catalyze efficient template-dependent synthesis using GNA as the template is of particular interest because GNA is u...

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Bibliografiske detaljer
Main Authors: Tsai, Ching-Hsuan, Chen, Jingyang, Szostak, Jack W.
Format: Artigo
Sprog:Inglês
Udgivet: National Academy of Sciences 2007
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC1976233/
https://ncbi.nlm.nih.gov/pubmed/17785419
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0704211104
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