Cell adhesion induces p27Kip1-associated cell-cycle arrest through down-regulation of the SCF(Skp2) ubiquitin ligase pathway in mantle-cell and other non-Hodgkin B-cell lymphomas

Mounting evidence suggests that dynamic interactions between a tumor and its microenvironment play a critical role in tumor development, cell-cycle progression, and response to therapy. In this study, we used mantle cell lymphoma (MCL) as a model to characterize the mechanisms by which stroma regula...

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Bibliographic Details
Main Authors: Lwin, Tint, Hazlehurst, Lori A., Dessureault, Sophie, Lai, Raymond, Bai, Wenlong, Sotomayor, Eduardo, Moscinski, Lynn C., Dalton, William S., Tao, Jianguo
Format: Artigo
Language:Inglês
Published: American Society of Hematology 2007
Subjects:
Neoplasia
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC1975846/
https://ncbi.nlm.nih.gov/pubmed/17502456
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2006-11-060350
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