A p53-type response element in the GDF15 promoter confers high specificity for p53 activation

GDF15 is a transcriptional target gene for p53 and its family members, p63 and p73. Its promoter region contains two p53-type response elements, RE1 and RE2, and RE2 confers p53-specific transactivation. RE2 contains several mismatches from the canonical p53 response element (RRRCWWGYYY). Two mismat...

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Main Authors: Osada, Motonobu, Park, Hannah Lui, Park, Min Joo, Liu, Jun-Wei, Wu, Guojun, Trink, Barry, Sidransky, David
Formato: Artigo
Idioma:Inglês
Publicado em: 2007
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC1975780/
https://ncbi.nlm.nih.gov/pubmed/17276395
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bbrc.2007.01.089
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