Application of a BRAF Pyrosequencing Assay for Mutation Detection and Copy Number Analysis in Malignant Melanoma

Mutations in the BRAF gene are found in the majority of cutaneous malignant melanomas and subsets of other tumors. These mutations lead to constitutive activation of BRAF with increased downstream ERK (extracellular signal-regulated kinase) signaling; therefore, the development of RAF kinase inhibit...

Полное описание

Сохранить в:
Библиографические подробности
Главные авторы: Spittle, Cynthia, Ward, M. Renee, Nathanson, Katherine L., Gimotty, Phyllis A., Rappaport, Eric, Brose, Marcia S., Medina, Angelica, Letrero, Richard, Herlyn, Meenhard, Edwards, Robin H.
Формат: Artigo
Язык:Inglês
Опубликовано: American Society for Investigative Pathology 2007
Предметы:
Regular Articles
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC1975103/
https://ncbi.nlm.nih.gov/pubmed/17690212
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2353/jmoldx.2007.060191
Метки: Добавить метку
Нет меток, Требуется 1-ая метка записи!

Схожие документы