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Disposition of the prodrug 4-(bis (2-chloroethyl) amino) benzoyl-L-glutamic acid and its active parent drug in mice.

A novel therapy for improving selectivity in cancer chemotherapy aims to modify distribution of a cytotoxic drug by generating it selectively at tumour sites. In this approach an antibody-enzyme conjugate is allowed to localise at the tumour sites before injecting a prodrug which is converted to an...

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Autors principals: Antoniw, P., Springer, C. J., Bagshawe, K. D., Searle, F., Melton, R. G., Rogers, G. T., Burke, P. J., Sherwood, R. F.
Format: Artigo
Idioma:Inglês
Publicat: Nature Publishing Group 1990
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Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC1971568/
https://ncbi.nlm.nih.gov/pubmed/2257218
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