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The cleaved peptide of the thrombin receptor is a strong platelet agonist

Thrombin cleaves its G-protein-linked seven-transmembrane domain receptor, thereby releasing a 41-aa peptide and generating a new amino terminus that acts as a tethered ligand for the receptor. Peptides corresponding to the new amino terminal end of the proteolyzed seven-transmembrane domain thrombi...

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Udgivet i:Proc Natl Acad Sci U S A
Principais autores: Furman, Mark I., Liu, Longbin, Benoit, Stephen E., Becker, Richard C., Barnard, Marc R., Michelson, Alan D.
Format: Artigo
Sprog:Inglês
Udgivet: National Academy of Sciences 1998
Fag:
Biological Sciences
Online adgang:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC19698/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/9501219/
https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.95.6.3082
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