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Sustained elevation of extracellular dopamine causes motor dysfunction and selective degeneration of striatal GABAergic neurons

Dopamine is believed to contribute to the degeneration of dopamine-containing neurons in the brain. However, whether dopamine affects the survival of other neuronal populations has remained unclear. Here we document that mice with persistently elevated extracellular dopamine, resulting from inactiva...

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Hlavní autoři: Cyr, Michel, Beaulieu, Jean-Martin, Laakso, Aki, Sotnikova, Tatyana D., Yao, Wei-Dong, Bohn, Laura M., Gainetdinov, Raul R., Caron, Marc G.
Médium: Artigo
Jazyk:Inglês
Vydáno: National Academy of Sciences 2003
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On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC196922/
https://ncbi.nlm.nih.gov/pubmed/12958210
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1831768100
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