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A small molecule HIV-1 inhibitor that targets the HIV-1 envelope and inhibits CD4 receptor binding

BMS-378806 is a recently discovered small molecule HIV-1 inhibitor that blocks viral entrance to cells. The compound exhibits potent inhibitory activity against a panel of R5-(virus using the CCR5 coreceptor), X4-(virus using the CXCR4 coreceptor), and R5/X4 HIV-1 laboratory and clinical isolates of...

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Publicat a:Proc Natl Acad Sci U S A
Autors principals: Lin, Pin-Fang, Blair, Wade, Wang, Tao, Spicer, Timothy, Guo, Qi, Zhou, Nannan, Gong, Yi-Fei, Wang, H.-G. Heidi, Rose, Ronald, Yamanaka, Gregory, Robinson, Brett, Li, Chang-Ben, Fridell, Robert, Deminie, Carol, Demers, Gwendeline, Yang, Zheng, Zadjura, Lisa, Meanwell, Nicholas, Colonno, Richard
Format: Artigo
Idioma:Inglês
Publicat: National Academy of Sciences 2003
Matèries:
Biological Sciences
Accés en línia:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC196918/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/12930892/
https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.1832214100
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