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Genetic regulation of telomere-telomere fusions in the yeast Saccharomyces cerevisae

Yeast strains with mutations in both TEL1 and MEC1 have short telomeres and elevated rates of chromosome deletions. By using a PCR assay, we demonstrate that mec1 tel1 strains also have telomere–telomere fusions (T-TFs). T-TFs require Lig4p (a ligase required for nonhomologous end-joining DNA repair...

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Udgivet i:Proc Natl Acad Sci U S A
Principais autores: Mieczkowski, Piotr A., Mieczkowska, Joanna O., Dominska, Margaret, Petes, Thomas D.
Format: Artigo
Sprog:Inglês
Udgivet: National Academy of Sciences 2003
Fag:
Biological Sciences
Online adgang:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC196892/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/12963812/
https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.1934561100
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