Resistance of virus to extinction on bottleneck passages: Study of a decaying and fluctuating pattern of fitness loss
RNA viruses display high mutation rates and their populations replicate as dynamic and complex mutant distributions, termed viral quasispecies. Repeated genetic bottlenecks, which experimentally are carried out through serial plaque-to-plaque transfers of the virus, lead to fitness decrease (measure...
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| Publicat a: | Proc Natl Acad Sci U S A |
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| Autors principals: | , , , , |
| Format: | Artigo |
| Idioma: | Inglês |
| Publicat: |
National Academy of Sciences
2003
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| Matèries: | |
| Accés en línia: | https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC196888/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/12960384/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.1332668100 |
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