Resistance of virus to extinction on bottleneck passages: Study of a decaying and fluctuating pattern of fitness loss

RNA viruses display high mutation rates and their populations replicate as dynamic and complex mutant distributions, termed viral quasispecies. Repeated genetic bottlenecks, which experimentally are carried out through serial plaque-to-plaque transfers of the virus, lead to fitness decrease (measure...

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Detaylı Bibliyografya
Asıl Yazarlar: Lázaro, Ester, Escarmís, Cristina, Pérez-Mercader, Juan, Manrubia, Susanna C., Domingo, Esteban
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: National Academy of Sciences 2003
Konular:
Biological Sciences
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC196888/
https://ncbi.nlm.nih.gov/pubmed/12960384
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1332668100
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