Resistance of virus to extinction on bottleneck passages: Study of a decaying and fluctuating pattern of fitness loss

RNA viruses display high mutation rates and their populations replicate as dynamic and complex mutant distributions, termed viral quasispecies. Repeated genetic bottlenecks, which experimentally are carried out through serial plaque-to-plaque transfers of the virus, lead to fitness decrease (measure...

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Veröffentlicht in:	Proc Natl Acad Sci U S A
Hauptverfasser:	Lázaro, Ester, Escarmís, Cristina, Pérez-Mercader, Juan, Manrubia, Susanna C., Domingo, Esteban
Format:	Artigo
Sprache:	Inglês
Veröffentlicht:	National Academy of Sciences 2003
Schlagworte:	Biological Sciences
Online-Zugang:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC196888/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/12960384/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.1332668100
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