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Coarse-grained sequences for protein folding and design

We present the results of sequence design on our off-lattice minimalist model in which no specification of native-state tertiary contacts is needed. We start with a sequence that adopts a target topology and build on it through sequence mutation to produce new sequences that comprise distinct member...

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Autori principali: Brown, Scott, Fawzi, Nicolas J., Head-Gordon, Teresa
Natura: Artigo
Lingua:Inglês
Pubblicazione: National Academy of Sciences 2003
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC196869/
https://ncbi.nlm.nih.gov/pubmed/12963815
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1931882100
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