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Influence of denatured and intermediate states of folding on protein aggregation
We simulate the aggregation thermodynamics and kinetics of proteins L and G, each of which self-assembles to the same β/β topology through distinct folding mechanisms. We find that the aggregation kinetics of both proteins at an experimentally relevant concentration exhibit both fast and slow aggreg...
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| Main Authors: | , , , , |
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| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
Cold Spring Harbor Laboratory Press
2005
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2253448/ https://ncbi.nlm.nih.gov/pubmed/15772307 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1110/ps.041177505 |
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